Palladium catalysts based on porous aromatic frameworks for vanillin hydrogenation: Tuning the activity and selectivity by introducing functional groups

The aim of the current work was to study the Mousepads activity of supported palladium catalysts based on porous aromatic frameworks (PAF) in vanillin hydrogenation, and to develop the methods for controlling their activity and selectivity by modifying the PAF structure with various functional groups.Using unmodified PAF-30, its sulfonated derivati

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392 Targeting One-Carbon Metabolism in Brain Cancer

OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis.There is great need for treatment options without side effects that are devastating to the quality of life for patients.GBM tumors can circumvent cellular damage by Bath mats upregulating antio

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Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension

Abstract Background Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics.There are currently no evidence-based therapeutics for headache in IIH, and consequently this is an important unmet Gearbox clinical need.Case series We report a ser

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